Tesamorelin Vs Ipamorelin Tesamorelin Vs Ipamorelin Tesamorelin vs Ipamorelin The debate between Tesamorelin and Ipamorelin centers on their distinct mechanisms, therapeutic uses, and side-effect profiles. While both peptides stimulate growth hormone release, they differ in potency, duration of action, and clinical indications. --- What Is Tesamorelin? Tesamorelin is a synthetic analogue of growth hormone-releasing hormone (GHRH). It mimics the natural hormone that signals the pituitary gland to produce growth hormone (GH). Clinical Uses Approved by the FDA for treating excess abdominal fat in HIV-infected patients with lipodystrophy. Used off-label for anti-aging, muscle building, and metabolic disorders. Dosage & Administration Typically injected subcutaneously once daily. Common dose: 2 mg per day; however, dosing varies by indication and patient response. How It Works Tesamorelin binds to GHRH receptors on the pituitary gland. This binding triggers a cascade that releases GH into circulation. The released GH then stimulates insulin-like growth factor-1 (IGF-1) production in the liver and other tissues, promoting lipolysis and muscle anabolism. --- What to Expect Onset of Action: 30–60 minutes after injection. Duration: Effects last up to 24 hours; IGF-1 levels rise within a week. Side Effects: Injection site reactions, edema, increased blood sugar, headaches. Monitoring: Regular blood tests for GH, IGF-1, glucose, and liver enzymes. What Is Ipamorelin? Ipamorelin is a selective growth hormone secretagogue (GHS).